First, you need to develop a strategic plan for your job search. It doesn't sound like you've got one at this point. Indiscriminately sending out resumes, like the 400 ads you answered, means you're likely going after a lot of low-level positions.

Start by identifying employers that value your particular background and skills, advises Sheryl Spanier, an executive career management consultant at Spanier & Co. in New York City. "You need to be clear about what you have to offer and who might be interested," she says.

Think broadly. "Instead of seeking to replace your lost position, consider seeking work that can be project related, outside your industry or an adaptation of your expertise to an allied field," says Ms. Spanier.

Next, search for networking connections who can recommend your candidacy before you send your resume to the firms you're targeting, says Doug Matthews, president and chief operating officer of Right Management, an outplacement firm based in Philadelphia. If you suspect that your age may be hurting your chances, trim the length of your resume, suggests Alane Baranello, managing director of Eileen Finn & Associates Inc., an executive recruiter in New York. "Make sure it only highlights the last 15 years of experience," she says. "There is no need to advertise 28 years of experience, as employers don't require it."